Cytomegalovirus (CMV)

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Record number: 
Adverse Occurrence type: 
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Organ transplant recipients were included in the study if they had CMV viremia, if they had received an organ from a CMV seropositive donor, and if there was at least 1 other recipient of an organ from the same donor who developed CMV viremia. A total of 21 donors and 47 recipients of organs that developed CMV viremia were included. Twenty-three recipients had a pretransplant donor/recipient CMV serostatus of D+/R+, and 24 had a serostatus of D+/R-.
Demonstration of imputability or root cause: 
Assessment of donor-to-recipient CMV transmission patterns by comparing CMV glycoprotein B genomic variants (gB genotype and gB gene sequence) between seropositive (R+) and seronegative (R-) recipients of organs from common donors (D+). Complex CMV transmission patterns after organ transplant because of the transmission of multiple strains from donor to recipients.
Imputability grade: 
1 Possible
Suggest references: 
Manuel O, Pang XL, Humar A, Kumar D, Doucette K, Preiksaitis JK. An assessment of donor-to-recipient transmission patterns of human cytomegalovirus by analysis of viral genomic variants. J Infect Dis. 2009 Jun 1;199(11):1621-8.
This paper is really quite interesting - and demonstrates CMV to multiple transplant recipients (D+/and R - or R+) with multiple types of organ transplants using strain typing, so there is more imputability data available. Really the point of this study is to demonstrate that recipients get CMV from their donor, from other sources, or from both. It isn't clear this is "new" information not already in the database. Will look for a place to consolidate CMV papers in another place already existing in the database.
Expert comments for publication: 
Some are possible, some are probable. There were different types of cases in this study.