Trypanosoma cruzi

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Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Transmission rates without recipient chemoprophylaxis is in the order of 18 to 22% according to different cases series.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
The present work describes the outcome of orthotopic liver transplantation in six patients with severe liver disease (Child Pugh C), with livers from donors serologically positive for Chagas disease (CD). Transplantations were performed from November 2000 to January 2005, and the patients received prophylactic treatment with benznidazole for 60 days, as recommended by the Brazilian Consensus in Chagas Disease. The transplantation procedures presented no technical problems, and all the patients were discharged from hospital. Five of them did not present side effects demanding interruption of the prophylactic treatment. Four of the patients were clinically well over 1 year after transplantation (mean follow-up of 42.1 months), with negative serological results for CD. Two patients died, one of them 6 months post surgery of sepsis due to biliary complication and other one due to pulmonary (tuberculosis) complications. They were both serologically negative for CD. These results suggest that liver transplantation from CD donors, followed by benznidazole prophylactic treatment, is an important therapeutic alternative for severe liver disease.
Demonstration of imputability or root cause: 
IWDT (intervention without documented transmission).
Reference attachment: 
Suggest references: 
D'Albuquerque LAC, Gonzalez AM, Filho HLVN, Copstein JLM, Larrea FIS, Mansero JMP, et al. Liver Transplantation from Deceased Donors Serologically Positive for Chagas Disease. American Journal of Transplantation. 2007;7(3):680-4.