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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
1 year
Alerting signals, symptoms, evidence of occurrence: 
Low-grade fever, pancytopenia, persistent splenomegaly.
Demonstration of imputability or root cause: 
Multiple basophilic cytoplasmatic inclusions in liver biopsy, massive presence of intracellular organisms on Giemsa stain and by culture in bone marrow aspirate (both negative prior to transplantation). Newly positive serology (1:1280). No serum was kept from the organ donor. However, one heart and two kidney transplant recipients from the same donor remained without clinical signs of leishmanial infection and have, at present, no serum antibodies against leishmania.
Imputability grade: 
1 Possible
Reference attachment: 
Suggest references: 
F. F. Horber; J. P. Lerut; J. Reichen; et al. Visceral leishmaniasis after orthotopic liver transplantation: impact of persistent splenomegaly. Transplant International 1993; 6: 55-57