Cryptococcus neoformans

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Transmission of cryptococcosis via donor solid organs is unusual, and only 10 cases have been reported.
Time to detection: 
5 days
Alerting signals, symptoms, evidence of occurrence: 
Hyperbilirubinemia, dyspnea, fever.
Demonstration of imputability or root cause: 
Recipient: pretransplant serum sample for cryptococcal specific antibodies and liver biopsy were negative. Two weeks after orthotopic liver transplantation (OLT): cryptococcus-like yeast in liver biopsy performed for hyperbilirubinemia and blood culture positive for Cryptococcus neoformans. Pretransplant donor liver biopsy negative.
Imputability grade: 
1 Possible
Reference attachment: 
Suggest references: 
Chang, C.M., Tsai, C.C., Tseng, C.E., Tseng, C.W., Tseng, K.C., Lin, C.W., Wei, C.K. and Yin, W.Y. (2014). Donor-derived Cryptococcus infection in liver transplant: case report and literature review. Exp Clin Transplant. 12(1):74-7.