Cryptococcus neoformans

Status: 
Ready to upload
Record number: 
1342
Adverse Occurrence type: 
Cryptococcus
MPHO Type: 
Liver
Estimated frequency: 
Transmission of cryptococcosis via donor solid organs is unusual, and only 10 cases have been reported.
Time to detection: 
5 days
Alerting signals, symptoms, evidence of occurrence: 
Hyperbilirubinemia, dyspnea, fever.
Demonstration of imputability or root cause: 
Recipient: pretransplant serum sample for cryptococcal specific antibodies and liver biopsy were negative. Two weeks after orthotopic liver transplantation (OLT): cryptococcus-like yeast in liver biopsy performed for hyperbilirubinemia and blood culture positive for Cryptococcus neoformans. Pretransplant donor liver biopsy negative.
Imputability grade: 
1 Possible
Groups audience: 
Infections -- Fungal
Infections
Keywords: 
Cryptococcus neoformans
liver
OLT (orthotopic liver transplantation)
hyperbilirubinemia
dyspnea
fever
biopsy
yeast
blood cultures
References: 
Donor-derived Cryptococcus infection in liver transplant: case report and literature review.
Solid organ transplant donors with central nervous system infection.
Reference attachment: 
PDF icon _ _ Cryptococcus, Chang, 2014.pdf
Suggest references: 
Chang, C.M., Tsai, C.C., Tseng, C.E., Tseng, C.W., Tseng, K.C., Lin, C.W., Wei, C.K. and Yin, W.Y. (2014). Donor-derived Cryptococcus infection in liver transplant: case report and literature review. Exp Clin Transplant. 12(1):74-7.