Salmonella choleraesuis

Status: 
Ready to upload
Record number: 
1317
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Transfusion-transmitted salmonellosis has only been described three times in the literature, including this report of multiple transmissions from a single donor infection.
Alerting signals, symptoms, evidence of occurrence: 
Between 12 August 1970 and 3 February 1971, seven cases of Salmonella cholerae-suis septicemia occurred in immunologically compromised patients hospitalized at the Clinical Center of the National Institutes of Health. One patient died, and two had long-term recurrences. Epidemiologic evidence implicated platelets as the common source, and one donor who donated to all seven patients was detected. S. cholerae-suis of the epidemic strain was isolated from the donor's plasma on three occasions. Clinical evaluation of the donor showed chronic osteomyelitis of the tibia. Thirty-four patients received platelets from this donor during the epidemic period, and a chart review showed a probable additional case of S. cholerae-suis septicemia. The most significant difference between patients who became ill and those who had no septicemia was coincidental administration of antibiotics to the latter group after transfusion with the contaminated platelets.
Demonstration of imputability or root cause: 
7 confirmed cases, and one probable. In a majority of the confirmed cases, the recipients grew Salmonella enterica serotype Choleraesuis from blood cultures, with septicemia, and/or close association of onset of septicemia to platelet transfusion. The donor also was culture positive for Salmonella enterica serotype Choleraesuis .
Imputability grade: 
3 Definite/Certain/Proven
Suggest new keywords: 
Salmonella enterica
Salomonella choleraesuis
Suggest references: 
Rhame FS, Root RK, et al. Salmonella septicemia from platelet transfusions. Study of an outbreak traced to a hematogenous carrier of Salmonella cholerae-suis. Ann Intern Med. 1973 May;78(5):633-41.
Note: 
Ready to upload once the taxonomy (Salmonella) is sorted (Evi)