Mycobacterium tuberculosis

The recipient had no known TB exposure and family contacts were well and tested negative for latent TB. The donor was a 42 year-old Vietnamese man who had emigrated to USA and died of acute intracranial hemorrhage. The donor had no history of TB or positive TB skin testing. Ante-mortem CT scan of the donor's chest showed no pulmonary infiltrates or granulomas. The genotype of the recipient's TB isolate did not match any TB isolates previously reported in Ohio where the recipient resided.The spacer oligonucleotide typing (spoligotype) of the recipient's TB isolate matched the spoligotype of thirty TB cases of Indo-oceanic lineage previously reported in the USA, 29 of which were among persons born in Vietnam or Cambodia. This is indirect evidence of TB transmission from the lung donor to the recipient. The two kidney recipients received isoniazid prophylaxis and did not develop M. tuberculosis infection. The liver recipient did not receive anti-TB prophylaxis and did not develop M. tuberculosis infection.