Status:
Ready to upload
Record number:
1293
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Transfusion-transmitted anaplasmosis frequency varies widely depending on the incidence of the disease in the donor population, which varies geographically.
Time to detection:
9 days
Alerting signals, symptoms, evidence of occurrence:
Fever, myalgia, pancytopenia, disseminated intravascular coagulopathy, multiorgan failure, intracytoplasmic morulae.
Demonstration of imputability or root cause:
This description only applies to the first case (the second is of uncertain imputability). Recipient had positive PCR for Anaplasma, and donation retention link was positive on PCR and by serology (1:40 IgM, >1:1,040 IgG) from one donor. The implicated donor had a history of hunting in wooded areas, including field dressing a deer and a rabbit. Recipient fully recovered with antibiotics.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
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Suggest references:
Annen K, Friedman K, Eshoa C, Horowitz M, Gottschall J, Straus T. Two cases of transfusion-transmitted Anaplasma phagocytophilum. Am J Clin Pathol 2012;137:562-5.
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Leiby, D.A. and Gill, J.E. (2004). Transfusion-transmitted tick-borne infections: a cornucopia of threats. Transfus Med Rev 18(4): 293-306.
Leiby, D.A. and Gill, J.E. (2004). Transfusion-transmitted tick-borne infections: a cornucopia of threats. Transfus Med Rev 18(4): 293-306.