Allergic/hypersensitivity reactions, platelets

Status:

Ready to upload

Record number:

1285

Adverse Occurrence type:

Allergic Reaction

MPHO Type:

Estimated frequency:

1.9% (Kaufman). Platelets stored in additive solution versus plasma 0.29% vs. 0.82%, respectively (Cohn).

Time to detection:

Within 4 hours

Alerting signals, symptoms, evidence of occurrence:

Common Terminology Criteria for Adverse Event (Kaufman). Biovigilance Component of National Healthcare Safety Network (Cohn)

Demonstration of imputability or root cause:

Clinical criteria as reviewed by expert panel

Imputability grade:

2 Probable

Groups audience:

Clinical complications

Keywords:

ATR (allergic transfusion reaction)

apheresis platelets

PAS (platelet additive solution)

References:

Transfusion-related adverse events in the Platelet Dose study.

A comparison of adverse reaction rates for PAS C versus plasma platelet units.

Reference attachment:

_ Platelet Adverse Events, Kaufman, 2015.pdf

_ Plt PAS-plasma Reactions, Cohn, 2014.pdf

Suggest references:

Kaufman, R.M., Assmann, S.F., Triulzi, D.J., Strauss, R.G., Ness, P., Granger, S. and Slichter, S.J. (2015). Transfusion-related adverse events in the Platelet Dose study. Transfusion 55(1):144-153; Cohn, C.S., Stubbs, J., Schwartz, J., Francis, R., Goss, C., Cushing, M., Shaz, B., Mair, D., Brantigan, B. and Heaton, A. (2014). A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion54:1927-1934.