Transfusion-associated graft versus host disease (TAGVHD)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Retrospective review over ten years. No denominator data available.
Alerting signals, symptoms, evidence of occurrence: 
Fever, rash, abdominal pain, diarrhea, nausea and vomiting, cough, pancytopenia, elevated bilirubin and liver function tests.
Demonstration of imputability or root cause: 
Fresh whole blood transfusions, non-irradiated, mostly from family members. Skin biopsy. Bone marrow aspirate.
Imputability grade: 
2 Probable
Groups audience: 
Reference attachment: 
Suggest references: 
Aoun, E., Shamseddine, A., Chehal, A., Obeid, M. and Taher, A. (2003). Transfusion-associated GVHD: 10 years' experience at the American University of Beirut-Medical Center. Transfusion43(12):1672-76.