Transfusion-associated graft versus host disease (TAGVHD)

Status: 
Ready to upload
Record number: 
1282
Adverse Occurrence type: 
Graft versus host disease
MPHO Type: 
Red blood cells
Estimated frequency: 
Retrospective review over ten years. No denominator data available.
Alerting signals, symptoms, evidence of occurrence: 
Fever, rash, abdominal pain, diarrhea, nausea and vomiting, cough, pancytopenia, elevated bilirubin and liver function tests.
Demonstration of imputability or root cause: 
Fresh whole blood transfusions, non-irradiated, mostly from family members. Skin biopsy. Bone marrow aspirate.
Imputability grade: 
2 Probable
Groups audience: 
Clinical complications
Keywords: 
fever
cutaneous rash
abdominal pain
diarrhea
nausea
vomiting
cough
pancytopenia
bilirubin elevation
elevated liver enzymes
TAGVHD (transfusion associated graft versus host disease)
RBC (red blood cell)
non irradiated
skin biopsy
bone marrow biopsy
References: 
Transfusion-associated GVHD: 10 years' experience at the American University of Beirut-Medical Center.
Reference attachment: 
PDF icon * TAGVHD, Aoun, 2003.pdf
Suggest references: 
Aoun, E., Shamseddine, A., Chehal, A., Obeid, M. and Taher, A. (2003). Transfusion-associated GVHD: 10 years' experience at the American University of Beirut-Medical Center. Transfusion43(12):1672-76.