Transfusion-associated graft versus host disease (TAGVHD)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report. Patient with chronic lymphocytic leukemia (CLL) treated with fludarabine and later autologous stem cell transplant.
Time to detection: 
10 days
Alerting signals, symptoms, evidence of occurrence: 
Fever, skin rash, diarrhea, abnormal liver function tests, delayed engraftment.
Demonstration of imputability or root cause: 
Skin biopsy, HLA typing. Donor of non-irradiated red cell transfusion identified. Red blood cells stored for 6 days.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
delayed engraftment, nonirradiated blood product
Reference attachment: 
Suggest references: 
Hutchinson, K., Kopko,P.M., Muto, K.N., Tuscano, J., O'Donnell, R.T., Holland, P.V., Richman, C., Paglieroni, T.G. and Wun, T. (2002). Early diagnosis and successful treatment of a patient with transfusion-associated GVHD with autologous peripheral blood progenitor cell transplantation. Transfusion 42(12):1567-72.
Expert comments for publication: 
Successful treatment following early identification and re-transplant.