Status:
Ready to upload
Record number:
1280
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case report. Patient with chronic lymphocytic leukemia (CLL) treated with fludarabine and later autologous stem cell transplant.
Time to detection:
10 days
Alerting signals, symptoms, evidence of occurrence:
Fever, skin rash, diarrhea, abnormal liver function tests, delayed engraftment.
Demonstration of imputability or root cause:
Skin biopsy, HLA typing. Donor of non-irradiated red cell transfusion identified. Red blood cells stored for 6 days.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
delayed engraftment, nonirradiated blood product
Reference attachment:
Suggest references:
Hutchinson, K., Kopko,P.M., Muto, K.N., Tuscano, J., O'Donnell, R.T., Holland, P.V., Richman, C., Paglieroni, T.G. and Wun, T. (2002). Early diagnosis and successful treatment of a patient with transfusion-associated GVHD with autologous peripheral blood progenitor cell transplantation. Transfusion 42(12):1567-72.
Expert comments for publication:
Successful treatment following early identification and re-transplant.