Status:
Ready to upload
Record number:
1277
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case report
Time to detection:
Hours
Alerting signals, symptoms, evidence of occurrence:
Onset of a diffuse erythematous skin eruption occurred several hours after platelet and red cell transfusion.
Demonstration of imputability or root cause:
Skin biopsy and cytology. Atypicaly lymphoid infiltrate in a stem cell transplant recipient: CD30-positive atypical reactive T cells, CD4, CD5, with an aberrant loss of CD7 expression, often applied as a criterion to distinguish lymphoma and benign reactive process. Additional history revealed that the patient had received a transfusion of RBCs and platelets at an outside institution for her worsening anemia and thrombocytopenia only a few hours before the development of the eruption.
Imputability grade:
2 Probable
Groups audience:
Keywords:
Suggest new keywords:
cytology, lymphoid infiltrate
Reference attachment:
Suggest references:
Gan, Y., Shinohara, M.M., Tosenbach, M., Elder, D., Frey, N. and Bagg, A. (2011). Transient blood transfusion reaction masquerading as a post-transplantation lymphoproliferative disorder mimicking acute leukemia cutis. J Clin Oncol 29(29):e751-753.
Note:
Introduce new voice in the taxonomy: Harm to a recipient/Miscellaneous complications/Other (Evi)
Expert comments for publication:
This case was instructive at several levels and illustrated the central role of a clinicopathologic correlation in the evaluation of abnormal skin biopsies. Diagnostic considerations evolved (or, rather, were considerably varied) from GVHD to leukemia cutis to post-transplantation lymphoproliferative disorder to a spontaneously resolving blood transfusion reaction, albeit one that was rather atypical and quite alarming histologically.