Transient Blood Transfusion Reaction, lymphoproliferation

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Onset of a diffuse erythematous skin eruption occurred several hours after platelet and red cell transfusion.
Demonstration of imputability or root cause: 
Skin biopsy and cytology. Atypicaly lymphoid infiltrate in a stem cell transplant recipient: CD30-positive atypical reactive T cells, CD4, CD5, with an aberrant loss of CD7 expression, often applied as a criterion to distinguish lymphoma and benign reactive process. Additional history revealed that the patient had received a transfusion of RBCs and platelets at an outside institution for her worsening anemia and thrombocytopenia only a few hours before the development of the eruption.
Imputability grade: 
2 Probable
Groups audience: 
Suggest new keywords: 
cytology, lymphoid infiltrate
Suggest references: 
Gan, Y., Shinohara, M.M., Tosenbach, M., Elder, D., Frey, N. and Bagg, A. (2011). Transient blood transfusion reaction masquerading as a post-transplantation lymphoproliferative disorder mimicking acute leukemia cutis. J Clin Oncol 29(29):e751-753.
Introduce new voice in the taxonomy: Harm to a recipient/Miscellaneous complications/Other (Evi)
Expert comments for publication: 
This case was instructive at several levels and illustrated the central role of a clinicopathologic correlation in the evaluation of abnormal skin biopsies. Diagnostic considerations evolved (or, rather, were considerably varied) from GVHD to leukemia cutis to post-transplantation lymphoproliferative disorder to a spontaneously resolving blood transfusion reaction, albeit one that was rather atypical and quite alarming histologically.