Febrile nonhemolytic transfusion reactions (FNHTR) among the elderly

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Febrile, non-hemolutic reaction rate for RBC transfusions in an elderly US population: 70.5 per 100,000 inpatient transfusion stays. Odds of reaction occurrence increase with increasing number of units transfused, female vs. male (OR=1.15), and patients with lymphoma (OR=1.22) and leukemia (OR=1.90). Rates increase with 1-year history of blood transfusion and decrease with increasing patient age.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Diagnosis based on ICD-9-CM coding. Specific time interval not stated. Fever, chills, rigors, headache, nausea and/or vomiting.
Demonstration of imputability or root cause: 
Retrospective administrative record review subject to over- and under- reporting and misclassifiction.
Imputability grade: 
2 Probable
Groups audience: 
Reference attachment: 
Suggest references: 
Menis, M., Forshee, R.A., Anderson, S.A., McKean, S., Gondalia, R., Warnock, R., Johnson, C., Mintz, P.D., Worrall, C.M., Kelman, J.A. and Izurieta, H.S. (2014). Febrile non-haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011-2012. Vox Sang DOI: 10.1111/vox.12215