Acute Hemolytic Transfusion Reaction (AHTR), Bombay

Status:

Ready to upload

Record number:

1269

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Case report

Alerting signals, symptoms, evidence of occurrence:

Patient was transfused with 5-10 mL of blood and developed marked sweating all over the body, chills, rigor, chest pain and dyspnea.

Demonstration of imputability or root cause:

Patient demonstrated to have Bombay phenotype and Bombay units were compatible

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

AHTR (acute hemolytic transfusion reaction)

RBC (red blood cell)

References:

Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping.

Suggest new keywords:

Bombay

Reference attachment:

* AHTR bombay, Malhotra, 2014.pdf

Suggest references:

Malhotra, S., Dhawan, H.K., Jain, A., Sachdev, S. and Marwaha, N. (2014). Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping. Indian J Hematol Blood Transfu 30(Suppl1):108-110.

Expert comments for publication:

Elegant documentation of a very rare occurrence of Bombay phenotype. This was not anticipated as the transfusing institution does not perform antibody screens prior to transfusion. The donor was documented to have Bombay phenotype both by absence of binding with a lectin with H specificity and compatibility with units from a known Bombay donor.