Status:
Ready to upload
Record number:
1268
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case report
Time to detection:
5 minutes
Alerting signals, symptoms, evidence of occurrence:
Red-colored urine.
Demonstration of imputability or root cause:
Hemoglobinuria, no other symptoms.
Imputability grade:
1 Possible
Groups audience:
Keywords:
References:
Reference attachment:
Suggest references:
Mun, S.H., Lee, S.H. and No, M.Y. (2012). A case of acute hemolytic transfusion reaction due to anti-Di(a) antibody -A case report. Korean J Anesthesiol 63(4):353-356.
Expert comments for publication:
Transfusion work up included presence of hemoglobinuria but no red cells in urine consistent with intravascular RBC lysis. However, the workup found the implicated unit to be compatible with the patient plasma, despite a circulating anti-Di(a) antibody. They do not say that the unit (or subsequently the donor) was documented to be Di(a)+. If hemolysis was this rapid (within 5 minutes of administration) I would expect that the strength of the serologic reaction to be quite strong. There are multiple other explanations for immediate hemolysis including issues of storage (too hot/cold) exposure to hypotonic solutions etc, that could also have yielded a similar outcome.