Acute Hemolytic Transfusion Reaction (AHTR), anti-c

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Fever, chills, dyspnea, bilateral loin pain.
Demonstration of imputability or root cause: 
Clinical and serology results, hemoglobinuria.
Imputability grade: 
2 Probable
Groups audience: 
Reference attachment: 
Suggest references: 
Pradhan, D. and Chaudhary, R. (1999). Acute intravascular haemolytic transfusion reaction due to anti-c undetected by conventional pretransfusion cross-matching tests. Am J Hematol 61(1):82-83
Expert comments for publication: 
A striking finding was the discordancy between strongly positive antibody screen using polyethylene glycol antiglobulin test (PEG-AGT) but not with saline or enzyme treated crossmatches.