Acute Hemolytic Transfusion Reaction (AHTR), anti-Co(b)

Status:

Ready to upload

Record number:

1266

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Case report

Time to detection:

minutes

Alerting signals, symptoms, evidence of occurrence:

Severe chills, brown urine after the transfusion of 250mL whole blood

Demonstration of imputability or root cause:

Weak positive DAT, increased bilirubin

Imputability grade:

1 Possible

Groups audience:

Clinical complications

Keywords:

AHTR (acute hemolytic transfusion reaction)

RBC (red blood cell)

DAT (direct antiglobulin test)

hyperbilirubinemia

References:

Anti-Cob causing acute hemolytic transfusion reaction.

Reference attachment:

* AHTR anti Co(b), Lee, 1982.pdf

Suggest references:

Lee, E.L. and Bennett, C. (1982). Anti-Cob causing acute hemolytic transfusion reaction. Transfusion 22(2):159-160.

Expert comments for publication:

Problematic aspects include weakness of serologic reaction and the fact that the antibody appeared to react to 33% of units, yet only ~11% would be expected to be Co(b)+.