Acute Hemolytic Transfusion Reaction (AHTR), anti-Do(b)

Status:

Ready to upload

Record number:

1264

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Case Report

Time to detection:

Hours

Alerting signals, symptoms, evidence of occurrence:

Fever, lower back pain and hemoglobinemia.

Demonstration of imputability or root cause:

Demonstration that the serologic reaction was much stronger against Do(b)+ cells than Do(b)- cells.

Imputability grade:

2 Probable

Groups audience:

Clinical complications

Keywords:

AHTR (acute hemolytic transfusion reaction)

RBC (red blood cell)

References:

The first reported case of anti-Dob causing an acute hemolytic transfusion reaction.

Reference attachment:

* AHTR antiDo(b), Halverson, 1994.pdf

Suggest references:

Halverson, G., Shanahan, E., Santiago, I., Mabile, R., Thurrell, T., Strupp, A.M., Wolf, C.E., Spruell, P. and Moulds, M.K. (1994). The first reported case of anti-Dob causing an acute hemolytic transfusion reaction. Vox Sang 66(3):206-209.

Expert comments for publication:

Dombrock antibodies, anti-Do(a) and -Do(b), have been responsible for immediate and delayed hemolytic transfusion reactions.