Status:
Ready to upload
Record number:
1258
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case Report. Acute hemolytic transfusion reactions following the administration of ABO-incompatible plasma in platelet concentrates have been reported but their potential severity is often not appreciated since it is not common.
Time to detection:
During transfusion
Alerting signals, symptoms, evidence of occurrence:
During transfusion of type O apheresis platelets into a type A recipient, patient experienced chills, back pain. Blood pressure dropped from 150/80 mmHg pretransfusion to 110/40 mmHg posttransfusion; pulse rate increased from 96 to 180; temperature rose from 98.6 to 103.4 °F. Bleeding from the gums and intravenous sites was noted and disseminated intravascular coagulation was documented by laboratory studies.
Demonstration of imputability or root cause:
Hemolysis in patients serum and serology reaction, including a positive direct antiglobulin test and anti-A eluted from the patient's cells.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Reference attachment:
Suggest references:
Conway, L.T. and Scott, E.P. (1984). Acute hemolytic transfusion reaction due to ABO incompatible plasma in a plateletapheresis concentrate. Transfusion 24(5):413-414.
Expert comments for publication:
Acute hemolytic transfusion reactions following the administration of ABO-incompatible plasma in platelet concentrates have been reported but their potential severity is often not appreciated since it is not common.