Status:
Ready to upload
Record number:
1249
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case Report. HTRs due to anti-P1 have rarely been reported.
Time to detection:
Immediately
Alerting signals, symptoms, evidence of occurrence:
After transfusion of 50 mL of P1 + blood, patient had AHTR with the following symptoms: hemoglobinemia, hemoglobinuria, increased blood pressure, temperature and respiration.
Demonstration of imputability or root cause:
After reaction DAT was positive (2+), IgG. The anti-P1 was IgM, and its titer was 16 at 37ºC (prewarmed) and 256 at 23ºC; it caused hemolysis of RBCs at 37ºC under conditions known to enhance hemolysis. The anti-P1 was detectable in eluates prepared from the patient's RBCs only when they were washed at RT. An indirect monocyte monolayer assay (MMA) indicated this IgM complement-binding antibody to be of clinical significance.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
AHR, anti-P1, hemolysis
Reference attachment:
Suggest references:
Arndt, P.A., Garratty, G., Marfoe, R.A. and Zegler, G.D. (1998). An acute hemolytic transfusion reaction caused by an anti-P1 that reacted at 37 degrees C. Transfusion 38(4):373-377.
Expert comments for publication:
The anti-P1descibed in this report was very unusual: it is only the second example described in the literature as cause of an AHTR since 1998.