Status:
Ready to upload
Record number:
1228
Adverse Occurrence type:
MPHO Type:
Time to detection:
13 days
Alerting signals, symptoms, evidence of occurrence:
Fever, hemoglobinemia, hemoglobinuria, oliguria, and a marked fall in hematocrit values developed in a patient with a bleeding peptic ulcer 13 days after he had received 4 units of apparently compatible blood. He went on to become frankly uremic and hyperkalemic, but eventually recovered.
Demonstration of imputability or root cause:
Results of routine serologic studies at the time of the transfusion reaction were normal, but an anti-Jkb antibody could be demonstrated when cells treated with trypsin were used in the indirect Coombs' test; the patient's blood type was found to be Jk(a+b-); the blood type of three of his four donors was Jk(b+).
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Reference attachment:
Suggest references:
Holland, P.V. and Wallerstein, R.O (1968). Delayed hemolytic transfusion reaction with acute renal failure. JAMA 204(11),1007-1008.