Delayed Hemolytic Transfusion Reaction (DHTR), anti-S, N, K, auto JK(b).

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Dolatkhah: Case Report
Time to detection: 
8 days
Alerting signals, symptoms, evidence of occurrence: 
Patient had a severe reaction consistent with tachycardia, fatigue, fever, back pain, chest discomfort, jaundice, nausea and anorexia. After eight days a severe DHTR was observed and laboratory tests revealed the presence of three antibodies (anti-N, anti-S,anti-K) and a monospecific autoanti-Jkb.
Demonstration of imputability or root cause: 
From the clinical point of view the DHTR could be attributed to the transfusion, but there are not other serological data confirming this hypothesis. The authors mention different procedures as the direct antiglobulin test and the eluate study but no results are provided in any case. So, there is not enough evidence.
Imputability grade: 
2 Probable
Groups audience: 
Suggest new keywords: 
"DHTR, alloimmunization, B-Thalassemia"
anti-S, N, K, auto JK(b).
Suggest references: 
Dolatkhah, R., Esfahani, A., Torabi, S.E., Kermani, I.A., Sanaat, Z., Aizei, J.E., Nikanfar, A., Chaboshi, S.H., Ghoreishi, Z. and Kermani, A.A. (2013). Delayed hemolytic transfusion reaction with multiple alloantibody (Anti S, N, K) and a monospecific autoanti-JK(b) in intermediate beta-thalassemia patient in Tabriz. Asian J Transfus Sci 7(2):149-150.