Delayed Hemolytic Transfusion Reaction (DHTR), anti-Di(b)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Hatano: Case Report
Time to detection: 
8 days
Alerting signals, symptoms, evidence of occurrence: 
Cardiac arrest associated with hyperkalemia in a massively transfused patient after emergency aortic surgery for acute aortic dissection.
Demonstration of imputability or root cause: 
Indirect antiglobulin testing demonstrated both anti-Di(b) and anti-E antibodies pre-transfusion, and elevation of their titers as the delayed hemolytic transfusion reaction evolved. Monocyte monolayer assay and flow cytometry gave evidence of the clinical significance of both antibodies.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
anti-Di(b); Diego;
Suggest references: 
Hatano, Y., Otusuka, S., Chousa, M., Saito, S., Nollet, K., Ohto, H., Shimabukuor, K., Takemura, H. and Hara, A. (2012). Fatal delayed hemolytic transfusion reaction associated with anti-Di(b) and anti-E. Transfus apher Sci 47(3):263-68.
Expert comments for publication: 
Diego antigen system