Citrate Toxicity

Status: 
Ready to upload
Record number: 
1193
Adverse Occurrence type: 
Citrate
MPHO Type: 
Red blood cells
Estimated frequency: 
Review article about citrate metabolism including toxicity.
Alerting signals, symptoms, evidence of occurrence: 
Dose dependent and clinical situation dependent latency. Bolus and prolonged administration may "overload" redistribution, metabolic, and excretion capability. Shivering, parasthesias, muscle cramps, carpopedal spasm, nausea, decreased blood pressure, decreased cardiac output. Prolnged QT interval on ECG.
Demonstration of imputability or root cause: 
Review article on citrate metabolism and toxicity, that includes clinical and animal model studies.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Clinical complications
Keywords: 
RBC (red blood cell)
red blood cell transfusion
toxicity
citrate
paresthesia
shivering
muscle cramps
low blood pressure
References: 
Citrate toxicity during massive blood transfusion.
Suggest new keywords: 
toxicity
citrate
Reference attachment: 
PDF icon * Citrate Toxicity, Dzik, 1988.pdf
Suggest references: 
Dzik, W.H. and Kirkley, S. A.(1988).Citrate toxicity during massive blood transfusion. Transfus Med Rev 2(2):76-94.
Note: 
New voice in the adv. occurrence taxonomy: Harm to a recipient/Miscellaneous complications/Toxicity/Citrate
Expert comments for publication: 
Excellent historic review article