Post transfusion purpura (PTP)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Among 4,336,338 inpatient transfusion stays for elderly beneficiaries during the study period, 78 had a post transfusion purpura (PTP) diagnosis code recorded, an overall rate of 1.8 per 100,000 stays.  Significantly higher odds of PTP were found for platelet (PLT)-containing transfusions, with greater number of units transfused, as well as for elderly with histories of cardiac arrhythmias (odds ratio [OR], 2.65; 95% confidence interval [CI], 1.43-4.93), coagulopathy (OR, 1.79; 95% CI, 1.01-3.21), leukemia (OR, 2.37; 95% CI, 1.07-5.26), transplant (OR, 2.68; 95% CI, 1.41-5.09), and other conditions.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
This retrospective claims-based study utilized large Medicare databases for calendar years 2011 and 2012. Transfusions of blood and blood components were identified by recorded ICD-9-CM procedure codes and revenue center codes, and PTP was ascertained via ICD-9-CM diagnosis code.
Demonstration of imputability or root cause: 
Medicare data base reports - not evaluated.
Imputability grade: 
Not Assessable
Groups audience: 
Suggest new keywords: 
PTP, elderly, Platelet,cardiac arrhythmia, coagulopathy, leukemia, transplant
Suggest references: 
Menis, M., Forshee R.A., Anderson, S.A., McKean, S., Gondalia, R., Warnock, R., Johnson, C., Mintz, P.D., Worrall, C.M., Kelman, J.A. and Izurieta, H.S. (2014). Posttransfusion purpura occurrence and potential risk factors among the inpatient US elderly, as recorded in large Medicare databases during 2011 through 2012. Transfusion