Status:
Ready to upload
Record number:
1178
Adverse Occurrence type:
MPHO Type:
Time to detection:
10 minutes
Alerting signals, symptoms, evidence of occurrence:
Low systolic blood pressure, respiratory distress, throat pain.
Demonstration of imputability or root cause:
Two bags of fresh-frozen plasma obtained from a donor (index donor) were implicated in two cases of anaphylactic transfusion reactions. The donor serum activated cord blood-derived mast cells (CBMCs) incubated with Patient 2 plasma. The IgG fraction of the donor serum induced degranulation of CBMCs sensitized with IgE or plasma containing a normal IgE concentration. Transfusion of a high concentration of the anti-IgE in the donor plasma was suggested to induce mast cell degranulation in the patients leading to the development of anaphylactic transfusion reactions.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest references:
Abe, T., Shimada, E., Takanashi, M., Takamura, T., Motoji, K., Okazaki, H., Satake, M. and Tadokoro, K. (2014). Antibody against immunoglobulin E contained in blood components as causative factor for anaphylactic transfusion reactions. Transfusion 54(8): 1953-60.