Anaphylactic Reaction induced by antibody against IgE

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
10 minutes
Alerting signals, symptoms, evidence of occurrence: 
Low systolic blood pressure, respiratory distress, throat pain.
Demonstration of imputability or root cause: 
Two bags of fresh-frozen plasma obtained from a donor (index donor) were implicated in two cases of anaphylactic transfusion reactions. The donor serum activated cord blood-derived mast cells (CBMCs) incubated with Patient 2 plasma. The IgG fraction of the donor serum induced degranulation of CBMCs sensitized with IgE or plasma containing a normal IgE concentration. Transfusion of a high concentration of the anti-IgE in the donor plasma was suggested to induce mast cell degranulation in the patients leading to the development of anaphylactic transfusion reactions.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
Abe, T., Shimada, E., Takanashi, M., Takamura, T., Motoji, K., Okazaki, H., Satake, M. and Tadokoro, K. (2014). Antibody against immunoglobulin E contained in blood components as causative factor for anaphylactic transfusion reactions. Transfusion 54(8): 1953-60.