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Adverse Occurrence type:
Pruritus and urticaria were manifest in 91.9 and 83.8% of all allergic transfusion reactions (ATRs), with more severe respiratory symptoms and angioedema occurring in less than 15% of cases. Total and aeroallergen-specific IgE was higher among subjects experiencing an ATR in comparison to control subjects (median total IgE, 55.5 kU/L vs. 8.3 kU/L, p = 0.002; and median aeroallergen-specific IgE, 0.57 kUa/L vs. 0.36 kUa/L, p = 0.046). A total of 630 ATRs occurred among 1418 apheresis platelet transfusions in which a split product was given to two patients--6 cases occurred in which both recipients had an allergic reation.
Time to detection:
Within 2 hours of transfusion
Alerting signals, symptoms, evidence of occurrence:
Puritis, urticaria,rash, wheezing.
Demonstration of imputability or root cause:
Review of reported reactions occuring within 2 hours of transfusion
Savage, W.J., Tobian, A.A.R., Savage, J.H.,Hamilton, R.G. and Ness, P.M. (2011). Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets. Transfusion 51(11): 2337-42; Savage, W.J., Tobian, A.A.R., Fuller, A.K., Wood, R.A., King, K.E. and Ness, P.M. (2011). Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes. Transfusion 51(8): 1716-22.