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Adverse Occurrence type:
Rare. 7.7% of Canadian blood donors have severe allergies.
Time to detection:
immediately - 4 days
Alerting signals, symptoms, evidence of occurrence:
Patient received two apheresis platelet transfusions from A) a donor with peanut allergy and B) subsequent apheresis platelet transfusion from a donor who had ingested peanuts. Immediately, patient developed pruritits and hives at time of transfusion. Four days following the index transfusion, while at home, she developed peri-oral and peri-orbital edema, and epiphora immediately after consuming peanut butter.
Demonstration of imputability or root cause:
Suspected passive transfer of IgE peanut antibodies following transfusion of platelet concentrate.
Ponnampalam, A., Growe, G., Loftus, P., Chipperfield, K. and Bigham, M. (2014). Acquired peanut hypersensitivity following platelet transfusion. Transfus Med DOI 10.1111/tme.12148