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Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Skin rash, fever, diarrhea, liver dysfunction, severe pancytopenia. Death due to sepsis and multi-organ failure.
Demonstration of imputability or root cause:
It can be important to have a high index of suspicion and to confirm the diagnosis early with tests for donor chimerism.
Smith, DM, et al, 2006. Graft-vs-host disease as a complication of lung transplantation. J Heart Lung Transplant 25:1175-7.