Transplantation of cornea released with (known) grade 3 cornea guttata

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Corneal specimens with Fuchs' dystrophy displayed numerous round highly reflecting guttae at the level of the corneal endothelium. Donor corneas with advanced guttae showed less numerous guttae. Among 168 organ cultured donor corneas issued for transplantation, low density guttae were found in 43 (25.6%) corneas. The endothelial cell density and figure coefficient were significantly lower and organ culture time was significantly higher in the cornea guttata group than in the control group. The presence of grouped guttae significantly decreased the adjusted graft survival. The incidence of postoperative stage 3 cornea guttata was significantly higher when grouped guttae were found (5/6) than when no guttae or scattered guttae were found (8/101).
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Slit lamp examination of recipient
Demonstration of imputability or root cause: 
Presence of guttae identified by means of light microscopy at the end of organ culture. Note: Specular microscopy is used for hypothermic preservation of corneas.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
Borderie VM, Sabolic V, Touzeau O. , Scheer S, Carvajal-Gonzalez S, Laroche L. Screening human donor corneas during organ culture for the presence of guttae. Br J Ophthalmol 2001; 85:272-6.