Autoimmune Thyroiditis with pancytopenia

Record number:

1151

Adverse Occurrence type:

Autoimmune

MPHO Type:

Marrow

Estimated frequency:

uncommon

Time to detection:

months - years

Alerting signals, symptoms, evidence of occurrence:

Hypothyroidism (bradycardia, weight gain, constipation) or hyperthyroidism (tachycardia, palpitation, weight loss, sweating, diarrhoea) with pancytopenia.

Demonstration of imputability or root cause:

Anti-thyroglobulin antibodies. Recipient: normal thyroid functions without anti-thyroglobulin antibodies before BMT. Donor: normal thyroid functions but positive for anti-thyroglobulin antibodies (subclinical state).

Imputability grade:

2 Probable

Keywords:

References:

Pancytopenia responding to treatment of hyperthyroidism: a clinical case and review of the literature.

Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation.

Reference attachment:

autoimmune thyroiditis, kishimoto.pdf

Suggest references:

Shaw B, Mehta AB. Pancytopenia responding to treatment of hyperthyroidism: a clinical case and review of the literature. Clin Lab Haematol 2002;24(6):385-7; Kishimoto, Y, et.al., 1997. Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation. Bone Marrow Transplant 19: 1041-3