Record number:
1150
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Among the 256 liver transplant recipients at a single transplant center with an International Classification of Diseases, Ninth Edition code for thrombocytopenia, 8 cases of new-onset ITP were identified, leading to an overall incidence of 0.7% in 1,105 consecutive liver transplant recipients over a 15-year period
Time to detection:
53.5 months (range, 1.9-173)
Alerting signals, symptoms, evidence of occurrence:
Subjects were considered to have ITP if there was evidence of new-onset severe, isolated immune mediated thrombocytopenia (i.e., platelet count <15,000 cells/mL) in the absence of other identifiable causes of thrombocytopenia, including microangiopathic hemolytic anemia/thrombotic thrombocytopenic purpura, as excluded by peripheral blood smear review. Hematology consultation was obtained on all patients at the time of diagnosis. Additionally, bone marrow biopsy and cell-bound antiplatelet antibody (CBPAb) testing were obtained in most patients but not required to make a diagnosis of ITP
Demonstration of imputability or root cause:
Positive for platelet associated IgG
Imputability grade:
3 Definite/Certain/Proven
Keywords:
References:
Suggest references:
Taylor, RM, et al, 2006. Immune thrombocytopenic purpura following liver transplantation: a case series and review of the literature. 12:781-91.