TACO (Transfusion-associated Circulatory Overload

Record number: 
1080
MPHO Type: 
Estimated frequency: 
Pediatric patients: 5.58 per 100,000 RBC transfusion; Adult patients: 3.75 per 100,000 RBC transfusions with both rates declining
Time to detection: 
<6 hours
Alerting signals, symptoms, evidence of occurrence: 
Canadian Consensus Conference criteria: acute onset, PaO2/FiO2<300 or Sp<90% on room air, bilateral CXR infiltrates, no evidence of circulatory overlaod, no ALI before transfusion
Demonstration of imputability or root cause: 
Expert panel review of all cases
Suggest references: 
Lieberman. L., Petrazko, T., Yi, Q.L., Hannach, B. and Skeate, R. (2014). Transfusion-related lung injury in children: a case series and review of the literature. Transfusion 54 (1): 57-64.