TACO (Transfusion-associated Circulatory Overload

Record number:

1080

Adverse Occurrence type:

Transfusion-Associated Circulatory Overload (TACO)

MPHO Type:

Estimated frequency:

Pediatric patients: 5.58 per 100,000 RBC transfusion; Adult patients: 3.75 per 100,000 RBC transfusions with both rates declining

Time to detection:

<6 hours

Alerting signals, symptoms, evidence of occurrence:

Canadian Consensus Conference criteria: acute onset, PaO2/FiO2<300 or Sp<90% on room air, bilateral CXR infiltrates, no evidence of circulatory overlaod, no ALI before transfusion

Demonstration of imputability or root cause:

Expert panel review of all cases

Keywords:

TRALI (transfusion related acute lung injury)

RBC (red blood cell)

pulmonary dysfunction

pediatric

transfusion reaction

bilateral pulmonary infiltrates

References:

Suggest references:

Lieberman. L., Petrazko, T., Yi, Q.L., Hannach, B. and Skeate, R. (2014). Transfusion-related lung injury in children: a case series and review of the literature. Transfusion 54 (1): 57-64.