Record number:
1068
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
14.4% of platelet transfusion episodes associated with acute transfusion reaction. Of these, 45.0% were transfusion associated dyspnea (acute respiratory distress within 24 hours of trasfusion cessation and all other causes or reaction ruled-out) and 4.2% TACO. No TRALI events. 10 of the 16 with TAD required respiratory support. No deaths.
Time to detection:
<24 hours
Alerting signals, symptoms, evidence of occurrence:
One year retrospective review of electonic medical records of all patients <18 years who received platelet transfusions. Inclusion criteria: reportable acute transfusion reactions per US Hemovigilance definition.
Demonstration of imputability or root cause:
For the authors assessment the TAD and TACO case imputability--probable.No CVC or B natriuretic peptide testing performed to differentiate TACO or TRALI from TAD.
Keywords:
Suggest references:
Li, N., Williams,L, Zhou, Z. and Wu, Y. Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system. Transfusion 2014; 54(6):1666-72.