Record number:
1058
Adverse Occurrence type:
MPHO Type:
Time to detection:
2 weeks
Alerting signals, symptoms, evidence of occurrence:
A donor developed symptoms of hepatitis 20 days after donation (28 days after returning from South America). The donor reported the illness 56 days after donation when contacted to schedule another visit. By this time, the red blood cell and frozen plasma components had been transfused. The recipient of the plasma, a 15-month-old female, tested positive for immunoglobulin M antibody to hepatitis A virus 43 days after transfusion. HAV PCR was positive at 46 days.The recipient had displayed mild, nonspecific symptoms approximately 2 weeks after transfusion. The recipient of the red cell unit died from illness before a diagnosis of infection could be determnied.
Demonstration of imputability or root cause:
On day 27 post donation, the donor tested positive for IgM anti-HAV serology resulting in a diagnosis of infection and a lookback on recipients. The recipient of the plasma tested reactive for IgM anti-HAV and HAV PCR, followed by elevate liver enzymes and jaundice.
Imputability grade:
2 Probable
Keywords:
Suggest references:
Hughes, J. A., Fontaine, M. J., Gonzalez, C. L., Layon, A. G., Goodnough, L. T. and Galel, S. A. (2014). Case report of a transfusion-associated hepatitis A infection. Transfusion DOI 10.1111/trf.12648.