Record number:
1050
Adverse Occurrence type:
MPHO Type:
Time to detection:
4 days
Alerting signals, symptoms, evidence of occurrence:
A 6-year-old boy recipient of bone marrow developed fever on day +4 and died one week later (Figueroa M, unpublished data).
Demonstration of imputability or root cause:
Dengue virus 4 was isolated from recipient's blood, ascitic fluid, and postmortem tissue samples. The donor developed fever and headache 2 days after the marrow was harvested. A diagnostic sample from the donor was positive for anti-dengue IgM antibodies, and titration in the same test against separate dengue antigens indicated that DEN-4 was the most likely infecting serotype.
Imputability grade:
2 Probable
Keywords:
Suggest references:
Rigau-Pérez JG, Vorndam AV, Clark GG. The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2):67-74.