Record number:
1018
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
First case of transfusion-transmitted L. monocytogenes infection reported in the literature.
Alerting signals, symptoms, evidence of occurrence:
Chills, headache and vomiting during transfusion. The day after the patient had persistent fever (range 38-38.5°C) with low systolic blood and elevated liver enzymes.
Demonstration of imputability or root cause:
L. monocytogenes serotype 1/2a, with the same antibiotic sensitivity spectrum, was isolated from both the apheresis platelet unit and the transfusion recipient. Interestingly, the donor's blood cultures performed the day of the platelet donation resulted negative. The blood donor was recalled to the Transfusion Centre and his blood was again cultured in aerobic and anaerobic blood culture bottles. This time, positive results were obtained after 31 hours. Subculture on horse blood agar revealed L. monocytogenes serotype1/2a.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
References:
Suggest references:
Tolomelli, G., Tazzari, P.L., Paolucci, M., Arpinati, M., Landini, M.P. and Pagliaro, P. (2014). Transfusion-related Listeria monocytogenes infection in a patient with acute myeloid leukaemia. Blood Transfus 12(4):611-614.