Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
30 yr old male penetrating keratoplasty (PK) for keratoconus. After one week developed eye pain, ciliary injection, graft edema, keratitic precipitates. Regrafted after 1 month. Excised button: Acanthamoeba cysts in stroma. Recurred again, had 3rd graft after 3 months. Donor asymptomatic.
Demonstration of imputability or root cause:
Definite. Two corneas from one donor transmitted infection after PK. Both infections shown to be from common source by genomic analysis (from same donor).