Olen - 29/09/2016 - 22:00

Adverse Occurrence type: 
Estimates Frequency: 
The authors presented data for three organ recipients (type of organ not described) from the same donor.
Time to detection: 
There is no information provided.
Alerting signals, symptoms, evidence of occurrence : 
The manuscript do not define the type of infection nor the symptoms the recipients suffered.
Demonstration of imputability or root cause: 
All three recipients affected with coccidioidomycosis were studied by a molecular technique (whole-genome sequence typing). By using this method it can be assume that Coccidioides immitis was the same in all three recipients. However, no microorganism was isolated in the donor so we can not definitively conclude that the donor was the source. Nevertheless, serology tested positive in the donor. All recipients and the donor lived in an endemic area.
Imputability grade: 
2 Probable
Groups audience: 
Revised in order to complete imputability and expert comments
Adverse occurrence description: 
Coccidioidomycosis donor-to-host transmission
Suggest references: 
Roy M, Park BJ, Chiller TM. Donor-derived fungal infections in transplant patients. Curr Fungal Infect Rep 2010;4:219-28.
Expert comments for publication: 
Whole-genome sequence typing seems a promising tool to determine if the infection in the recipient comes from the donor. However its usefulness in clinical practice is limited in order to make any decision in terms of therapy as you need the microorganism to perform the study.