Record to update:
MPHO Type:
Estimates Frequency:
Seems to be rare, and to be limited to donors with ages over 55 years, who had frequent donations within a 365 days period and who had multiple donations in their lifetime.
The study found that the CD4+ were <200 cells/microliter in 2 out of 20 donors with 3 to 19 donations in the past year, and in 6 out of 20 donors with 20 to 24 donations in the past year.
Time to detection:
Unknown; it is possible that some donors had lymphopenia for months or years prior to its discovery.
Alerting signals, symptoms, evidence of occurrence :
There are no associated signs/symptoms of the plateletpheresis-associated lymphopenia, and no apparent adverse effect on the donors' health.
Demonstration of imputability or root cause:
Most likely caused by recurrent removal of T-lymphocytes by the leukoreduction chamber of the apheresis instrument.
Imputability grade:
Not Assessable
Groups audience:
Suggest new keywords:
Plateletpheresis
Lymphopenia
Adverse occurrence description:
Lymphopenia, specifically lower CD4+ and CD8+ T-lymphocyte counts, associated with frequent plateletpheresis procedures performed with a leukoreduction system chamber
Suggest references:
Strauss RG. Effects on donors of repeated leukocyte losses during plateletpheresis. J Clin Apher. 1994;9(2):130-134.
Zonios DI, Falloon J, Bennett JE, et al. Idiopathic CD41 lymphocytopenia: natural history and prognostic factors [published correction appears in Blood. 2014;124(3):463]. Blood. 2008;112(2):287-294.
Strauss RG. Apheresis donor safety–changes in humoral and cellular mmunity. JClinApher. 1984;2(1):68-80.
Robbins G, Petersen CV, Brozovic´ B. Lymphocytopenia in donors undergoing regular platelet apheresis with cell separators. Clin Lab Haematol. 1985;7(3):225-230.
Richa E, Krueger P, Burgstaler EA, Bryant SC, Winters JL. The effect of double- and tripleapheresis platelet product donation on apheresis donor platelet and white blood cell
counts. Transfusion. 2008;48(7):1325-1332.
Expert comments for publication:
Lymphopenia, specifically lower CD4+ and CD8+ T-lymphocyte counts, was found to be associated with frequent plateletpheresis procedures performed with a leukoreduction system chamber apheresis instrument. The finding is usually incidental and there are no associated signs/symptoms of the plateletpheresis-associated lymphopenia, and no apparent adverse effect on the donors' health. The decrease in CD4+ and CD8+ cells is most likely caused by recurrent removal of T-lymphocytes by the leukoreduction chamber of the apheresis instrument.