Hemolysis secondary to IVIG

Status:

Ready to upload

Record number:

1766

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Plasma derivates

Estimated frequency:

Infrequent, not rare

Time to detection:

Immediate to first few days post infusion

Alerting signals, symptoms, evidence of occurrence:

Hemolysis, rapid drop in hct/hgb

Demonstration of imputability or root cause:

Positive DAT with eluate showing same specificity as identified in IVIG sample

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

plasma derivates

IVIG (intravenous immunoglobulin)

AHTR (acute hemolytic transfusion reaction)

hematocrit level

HgB (hemoglobin)

DAT (direct antiglobulin test)

References:

Hemolytic events after the administration of lyophilized versus liquid immune globulin: an analysis of a single manufacturer’s safety database

Suggest new keywords:

IVIG, hemolysis

Reference attachment:

IVIG hemolysis Berg_et_al-2015-Transfusion.pdf

Suggest references:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Hemolytic+events+after+the+administration+of+lyophilized+versus+liquid+immune+globulin%3A+an+analysis+of+a+single+manufacturer%E2%80%99s+safety+database

Note:

I think this is good to include as it indicates both lyophilized and liquid can be involved in AHTR but maybe another paper on hemolytic events and IVIG is needed.