%0 Journal Article %J //Transpl Infect Dis %D 2014 %T Three cases of donor-derived pulmonary tuberculosis in lung transplant recipients and review of 12 previously reported cases: opportunities for early diagnosis and prevention. %A Mortensen, E. %A Hellinger, W. %A Keller, C. %A Cowan, L. %A Shaw, T. %A Hwang, S. %A Pegues, D. %A Ahmedov, S. %A Salfinger, M. %A Bower, W. %K Donor Selection %K interferon gamma release assay %K Lung Transplantation %K Mycobacterium tuberculosis %X Introduction. Solid organ transplant recipients have a higher frequency of tuberculosis (TB) than the general population, with mortality rates of approximately 30%. Although donor-derived TB is reported to account for <5% of TB in solid organ transplants, the source of Mycobacterium tuberculosis infection is infrequently determined., Methods. We report 3 new cases of pulmonary TB in lung transplant recipients attributed to donor infection, and review the 12 previously reported cases to assess whether cases could have been prevented and whether any cases that might occur in the future could be detected and investigated more quickly. Specifically, we evaluate whether opportunities existed to determine TB risk on the basis of routine donor history, to expedite diagnosis through routine mycobacterial smears and cultures of respiratory specimens early post transplant, and to utilize molecular tools to investigate infection sources epidemiologically., Findings. On review, donor TB risk was present among 7 cases. Routine smears and cultures diagnosed 4 asymptomatic cases. Genotyping was used to support epidemiologic findings in 6 cases., Conclusion. Validated screening protocols, including microbiological testing and newer technologies (e.g., interferon-gamma release assays) to identify unrecognized M. tuberculosis infection in deceased donors, are warranted., E. Mortensen, W. Hellinger, C. Keller, L.S. Cowan, T. Shaw, S. Hwang, D. Pegues, S. Ahmedov, M. Salfinger, W.A. Bower. Three cases of donor-derived pulmonary tuberculosis in lung transplant recipients and review of 12 previously reported cases: opportunities for early diagnosis and prevention. Transpl Infect Dis 2014: 16: 67-75. All rights reserved, (C) 2014 John Wiley & Sons A/S %B //Transpl Infect Dis %I (1)Epidemic Intelligence Service Field Assignments Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA(2)Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA(3)Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, %C (C) 2014 John Wiley & Sons A/S %V 16 %P 67 - 75 %8 2014 %@ 1398-2273 %G eng %N 1 %< http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovfto&NEWS=N&AN=00128378-201402000-00008