%0 Journal Article %J Transplant infectious disease : an official journal of the Transplantation Society//Transpl Infect Dis %D 2007 %T Coccidioidomycosis in healthy persons evaluated for liver or kidney donation. %A Blair, J E %A Mulligan, D C %K *Coccidioides/im [Immunology] %K *Coccidioidomycosis/ep [Epidemiology] %K *Coccidioidomycosis/et [Etiology] %K *Kidney Transplantation/ae [Adverse Effects] %K *Liver Transplantation/ae [Adverse Effects] %K *Living Donors %K Adult %K Antibodies, Fungal/bl [Blood] %K Coccidioidomycosis/bl [Blood] %K Female %K Humans %K Longitudinal Studies %K Male %K Middle Aged %K Organ Transplantation/ae [Adverse Effects] %K Seroepidemiologic Studies %K United States/ep [Epidemiology] %X Coccidioidomycosis is a fungal infection caused by Coccidioides species endemic to the southwestern United States, where it poses unique challenges for transplant recipients. Donor-derived coccidioidomycosis has been documented, but its risk of transmission is not known. We prospectively screened 568 healthy persons requesting evaluation for possible liver or kidney donation. Twelve (2.1%) of the 568 donor candidates were seropositive (11 initially and 1 with seroconversion and symptomatic illness within 1 week after negative screening). Three of these 12 patients proceeded to kidney donation, and a fourth patient proceeded to liver donation. None of the 4 transplant recipients received special coccidioidal prophylaxis, although all were administered fluconazole according to standard antifungal prophylaxis protocols. At follow-up (7-54 months), no coccidioidomycosis was identified in any recipient. The prevalence of coccidioidal antibodies was low among potential organ donor candidates, but the risk of donor-derived coccidioidomycosis remains unknown and further study is warranted. %B Transplant infectious disease : an official journal of the Transplantation Society//Transpl Infect Dis %C Denmark %V 9 %P 78 - 82 %8 2007 %@ 1398-22731398-2273 %G eng %N 1 %< http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med5&NEWS=N&AN=17313480