TY - JOUR T1 - Impact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study. JF - //Transfus Med Y1 - 2013 A1 - Kanai, R. A1 - Iijima, T. A1 - Hashimoto, S. A1 - Nakazawa, H. A1 - Ohnishi, H. A1 - Yorozu, T. A1 - Ohkawa, R. A1 - Nojiri, T. A1 - Shimizu, M. A1 - Okazaki, H. KW - anti-HLA antibody KW - LPC KW - platelet KW - platelet concentrate KW - pulmonary distress KW - TACO KW - TRALI KW - transfusion AB - Objectives: To construct an alternative policy for the donor selection of platelet concentrate (PC), a clinical study exploring the features of lung injury following PC administration is needed., Background: Although a male-donor-only policy for plasma products appears to have efficiently reduced transfusion-related acute lung injury (TRALI), this policy may not be applied to PC because of supply shortages., Methods and Materials: We prospectively examined pulmonary function after the transfusion of PC in informed surgical patients treated at a tertiary university hospital in Japan. The contributions of immunoreactive substances contained in the PC to respiratory function after PC transfusion was then statistically examined., Results: Eighty-six patients (56 men, 30 women) were enrolled in the analysis. Fifty-four cases experienced respiratory failure (PaO2/FiO2 <300 mmHg) after transfusion. Five cases were diagnosed as possible TRALI based on permeability pulmonary oedema, while 23 cases were diagnosed as transfusion-associated circulatory overload (TACO) based on chest radiograph findings. A multivariate logistic regression analysis identified the presence of anti-granulocyte antibody as a significant predictor of possible TRALI [P = 0[middle dot]023; odds ratio (OR), 13[middle dot]0; 95% confidence interval (CI), 1[middle dot]4-118[middle dot]3]. Meanwhile, anti-leukocyte antibody class II was identified as a significant independent predictor of TACO (P = 0[middle dot]010; OR, 18[middle dot]4; 95% CI, 2[middle dot]0-170[middle dot]1)., Conclusions: Our data suggest that antibodies contained in PC may contribute to the deterioration of respiratory function after PC transfusion, although the diagnoses of TACO and TRALI may have overlapped among the patients with pulmonary distress in this cohort., (C) 1999?2012 John Wiley & Sons, Inc M1 - bu7, 9301182 PB - (1) Departments of Anesthesiology, Kyorin University School of Medicine(2) Department of Perioperative Medicine, School of Dentistry, Showa University(3) Research and Development Department, Central Blood Institute, Blood Service Headquarters, Japanese Re CY - (C) 1999?2012 John Wiley & Sons, Inc VL - 23 SN - 0958-7578 CP - 5 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovfto&NEWS=N&AN=00010826-201310000-00008 ID - 4339 ER -