TY - JOUR T1 - Incidence of Tuberculosis in Deceased-Organ Donors and Transmission Risk to Recipients in Spain. JF - //Transplantation Y1 - 2013 A1 - Coll, Elisabeth A1 - Torre-Cisneros, Julian A1 - Calvo, Ruben A1 - Garrido, Gregorio A1 - Matesanz, Rafael KW - donor KW - Donor-transmitted KW - solid-organ transplantation KW - Tuberculosis AB - Background: Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients., Methods: Retrospective cohort study, including all actual deceased donors in Spanish hospitals between January 1998 and June 2011 and all the recipients who had received an organ from donors identified as TB cases., Results: Six actual donors were identified as TB cases, representing an annual incidence of 30.6 cases/100,000 donors (95% CI, 4-58). Two cases did not become utilized donors, because TB was detected in the organ recovery and were therefore excluded. Annual incidence in utilized donors was 23 cases/100,000 donors (95% CI, 6-59). Annual incidence of the Spanish population in the same period was 17.5 cases/100,000 inhabitants (95% CI, 17-18). Annual incidence in actual donors belonging to the Romanian immigrant community was 2353 cases/100,000 donors (95% CI, 286-8242). Variations in the prophylactic strategy utilized in recipients were observed. TB was transmitted to three recipients (27.3% transmission), two of whom developed active TB., Conclusions: Incidence of TB in actual donors is greater than that of the general population (P<0.001). The risk of immigrant communities should be grouped according to the real incidence in donors. Transmissibility of TB is high; therefore, transplant teams should be immediately informed when TB donor transmission is suspected to prevent TB in the recipient., (C) 2013 by Lippincott Williams & Wilkins M1 - wej, 0132144 PB - (1) Organizacion Nacional de Trasplantes (ONT), Ministerio de Sanidad, Servicios Sociales e Igualdad (MSSSI), Madrid, Spain.(2) Department of Infectious Diseases, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC)-Hospital Universitario R CY - (C) 2013 by Lippincott Williams & Wilkins VL - 96 SN - 0041-1337 CP - 2 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovfto&NEWS=N&AN=00007890-201307270-00015 ID - 4287 ER -