TY - JOUR T1 - Pure red cell aplasia due to parvovirus B19 infection transmitted probably through hematopoietic stem cell transplantation JF - Transplant infectious disease : an official journal of the Transplantation Society Y1 - 2008 A1 - Wasak-Szulkowska,E. A1 - Grabarczyk,P. A1 - Rzepecki,P. KW - *Parvovirus B19, Human KW - Adult KW - DNA, Viral / analysis KW - Hematopoietic Stem Cell Transplantation / *adverse effects KW - Humans KW - Male KW - Parvoviridae Infections / complications / therapy / *transmission KW - Red-Cell Aplasia, Pure / *etiology AB - Human parvovirus B19 is a very common infectious pathogen in humans. In healthy subjects, B19 infection is the cause of a self-limiting subclinical erythroid aplasia, followed by rash or arthralgia. In immunocompromised patients B19 can cause chronic anemia. This report presents the case of a 19-year-old male who developed severe anemia shortly after successful allogeneic hematopoietic stem cell transplantation. His marrow showed selective erythroid aplasia, and real-time polymerase chain reaction assay confirmed parvovirus B19 infection. Despite repeated high-dose immunoglobulin treatment, he remained anemic. His hematological status markedly improved after cessation of immunosuppression. Retrospective examination of the donor's blood suggests that hematopoietic stem cells could be the source of infection. VL - 10 CP - 3 N1 - Wasak-Szulkowska, E Grabarczyk, P Rzepecki, P Denmark Transpl Infect Dis. 2008 Jun;10(3):201-5. Epub 2007 Jul 12. ID - 1608 ER -