TY - JOUR T1 - Herpes simplex virus 1 transmission through corneal transplantation JF - Lancet Y1 - 2001 A1 - Remeijer,L. A1 - Maertzdorf,J. A1 - Doornenbal,P. A1 - Verjans,G. M. A1 - Osterhaus,A. D. KW - *Herpesvirus 1, Human / genetics / immunology KW - *Keratoplasty, Penetrating KW - Adult KW - Antibodies, Viral / blood KW - DNA Fingerprinting KW - Glaucoma / *congenital / surgery KW - Humans KW - Keratitis, Herpetic / immunology / *transmission / virology KW - Male KW - Polymerase Chain Reaction KW - Reoperation KW - Tissue Donors KW - Virus Activation AB - Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea. VL - 357 ER - internal-pdf://Remeijer et al Herpes Simplex 1 Virus-0797119233/Remeijer et al Herpes Simplex 1 Virus.pdf CP - 9254 N1 - Remeijer, L Maertzdorf, J Doornenbal, P Verjans, G M Osterhaus, A D Case Reports Letter Research Support, Non-U.S. Gov't England Lancet Lancet. 2001 Feb 10;357(9254):442. ID - 1310 ER -