TY - JOUR T1 - Depressed immunity and the development of cancer JF - Cancer Detect Prev Y1 - 1994 A1 - Penn,I. KW - *Immune Tolerance KW - Acquired Immunodeficiency Syndrome / complications KW - Humans KW - Immunologic Deficiency Syndromes / *complications KW - Immunosuppressive Agents / adverse effects KW - Neoplasms / *etiology / immunology KW - Organ Transplantation / *adverse effects KW - Research Support, U.S. Gov't, Non-P.H.S. KW - Tumor Virus Infections / complications AB - Various disorders of immune competence are associated with increases in uncommon tumors, particularly non-Hodgkin's lymphomas (NHLs), which often exhibit unusual features: they are frequently extranodal, show a broad spectrum of lesions, ranging from benign polyclonal hyperplasia to frankly malignant monoclonal lymphomas, and are frequently localized to the brain. Of 7136 tumors in organ transplant recipients, the predominant lesions are NHLs, carcinomas of the skin and lips, carcinomas of the vulva/perineum, Kaposi's sarcoma (KS), and renal carcinomas. Skin cancers present unusual features: predominance of squamous cell carcinomas, young age of the patients, and a high incidence of multiple tumors. Cancers of the vulva/perineum occur at a much younger age than in the general population. In AIDS patients the most common malignancy is KS, which occurs in 14%, whereas NHLs afflict 2.9%. A variety of other tumors occur in these patients. The most common tumors in patients with primary immunodeficiency states are NHLs (49%), leukemias (13%), various carcinomas (9%), and Hodgkin's disease (7%). VL - 18 CP - 4 N1 - 0361-090X (Print) Journal Article Review ID - 1179 ER -