TY - JOUR T1 - Unexpected postmortem diagnosis of Acanthamoeba meningoencephalitis following allogeneic peripheral blood stem cell transplantation. JF - Am J Transplant Y1 - 2008 A1 - Pemán,J. A1 - Jarque,I. A1 - Frasquet,J. A1 - Alberola,C. A1 - Salavert,M. A1 - Sanz,J. A1 - Gomila,B. A1 - Esteban,G. KW - Acanthamoeba KW - Amebiasis KW - Animals KW - Humans KW - Meningoencephalitis KW - Peripheral Blood Stem Cell Transplantation AB - Meningoencephalitis caused by pathogenic free-living amebas is usually fatal. Only a few cases of Acanthamoeba meningoencephalitis, diagnosed at autopsy, have been reported following hematopoietic stem cell transplantation. We here report a case of Acanthamoeba meningoencephalitis following allogeneic peripheral blood stem cell transplantation with rapidly evolving neurologic symptoms that remained unexplained. Magnetic resonance imaging failed to show brain lesions and cerebrospinal fluid was negative for microbiological cultures. Definite diagnosis was an unexpected autopsy finding. As overall and teaching hospital autopsy rates are declining worldwide, we must emphasize the need of autopsy exams if we want to improve our knowledge as the best way to care for our patients. VL - 8 CP - 7 ID - 1156 ER -