TY - JOUR T1 - Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature JF - Nephrol Dial Transplant Y1 - 2007 A1 - Nickkholgh,A. A1 - Weitz,J. A1 - Encke,J. A1 - Sauer,P. A1 - Mehrabi,A. A1 - Buchler,M. W. A1 - Schmidt,J. A1 - Schemmer,P. KW - Adult KW - Age Factors KW - Aged KW - Graft Survival KW - Humans KW - Ischemia KW - Liver Transplantation / *methods KW - Living Donors KW - Middle Aged KW - Registries KW - Regression Analysis KW - Risk Factors KW - Tissue and Organ Procurement / methods KW - Treatment Outcome KW - Warm Ischemia AB - Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through a comprehensive review of the most recent findings and current opinions. Age, steatosis, positive viral hepatitis serology, intensive care unit stay, and history of malignancy in donor have been the matter of substantial debate in recent years and are therefore discussed in further detail here. Cold and warm ischemic times have also been discussed separately as they have been identified as important independent risk factors for mortality. The use of grafts with EDC provides an immediate expansion of the donor pool. However, in order to optimize effective utilization of EDC, attempts should be made to carefully match the most appropriate graft-recipient pair. VL - 22 Suppl 8 N1 - Nickkholgh, Arash Weitz, Jurgen Encke, Jens Sauer, Peter Mehrabi, Arianeb Buchler, Markus W Schmidt, Jan Schemmer, Peter Review England Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Nephrol Dial Transplant. 2007 Sep;22 Suppl 8:viii29-viii36. ID - 1085 ER -