TY - JOUR T1 - Organ donors with malignant gliomas: an update JF - Am J Transplant Y1 - 2004 A1 - Collignon,F. P. A1 - Holland,E. C. A1 - Feng,S. KW - *Tissue Donors KW - Brain Neoplasms / pathology KW - Central Nervous System Neoplasms / *pathology KW - Ethics KW - Glioma / *pathology KW - Humans KW - Models, Biological KW - Neoplasm Metastasis KW - Organ Transplantation / methods KW - Research Support, Non-U.S. Gov't KW - risk KW - Signal Transduction KW - Tissue and Organ Procurement / methods AB - The escalating shortage of organs motivates frequent reconsideration of concepts that guide the decision to accept or decline organs from donors with central nervous system (CNS) malignancy. Currently, a minority of patients who die annually of CNS malignancies are organ donors. Specifically, the organs of less than 0.5% of the 13 000 patients dying from glioma are procured and transplanted every year in the United States. This review seeks to clarify the risk of cancer transmission from transplantation of organs from donors with glioma. After considering historical precedence, we will systematically outline the clinical features of a potential organ donor with glioma that might reflect upon the risk of cancer transmission. We will then present recent knowledge regarding basic glioma biology that speaks to their metastatic potential and suggest rational strategies for the post-transplant management of recipients of organs from donors with glioma. VL - 4 CP - 1 N1 - 1600-6135 (Print) Journal Article Review ID - 364 ER -